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== Borland Genetics == | == Borland Genetics == | ||
[[File:Borland Logo.png||right| 350px|]] | |||
[https://www.borlandgenetics.com/ Borland Genetics] is an autosomal matching database with emphasis on reconstructing DNA of deceased individuals. It was founded by Kevin Borland in 2019. The website is dedicated to reconstructing DNA of deceased individuals by using samples from their descendants. The raw data files for the deceased individuals can then be uploaded to other sites that accept uploads. Many of the tools on the website are free, but there is also a subscription version that grants access to more advanced tools. Here is a list of all the tool: | |||
=== Core Utilities === | |||
'''*Ultimate Phaser:''' This free tool lets you compare two kits and then with the segments that match, assign the matching portions to an ancestor. You can instead choose to take the matching segments and take the DNA unique to one of individuals in that same spot (the dark side) and assign that DNA instead. (Can be accessed from the Chromosome Browser screen, by clicking the "Chromosome Browser" button on any of the matches to any of the kits in your DNA Inventory.) | |||
'''*Extract Segments:''' This lets you move segments from any mono kit to another individual's mono kit. (Can be accessed from the Kit Attributes screen, by clicking the "Explore in Kit Laboratory" button on any of the mono kits in your DNA Inventory.) | |||
'''*Chameleon:''' (Deprecated: Replaced by the Chameleon DNA Template Management Engine which automatically runs on the server and selects optimal settings. You no longer have to choose a project template and/or manually manage templates for use with tools that require multiple kits as input.) | |||
'''*Humpty Dumpty:''' Arguably the most important tool on the website. As you use each of the successive tools, you will end up with multiple mono kit that each have up to 50% of the target person's DNA. To make a better reconstruction that has 50-100% of the target person's DNA, you will need to merge these drafts together using the Humpty Dumpty tool. (Can be accessed by clicking the "View/Edit Donor Profile" button on any of the eligible donors in your DNA Inventory. | |||
Humpty Dumpty offers three options: | |||
* | **Humpty Dumpty Option 1: Merge Mono to Mono: This option is used to merge contributing mono DNA resources within a single child clade of the donor into a composite mono kit. From the resulting mono output kit, segments can be extracted that correspond to distinct ancestors of the donor, and therefore the output can be used as a building block for further DNA reconstruction. However, select this option only if the mono input kits were created by extracting only data from descendants of a single child of the donor. | ||
* | **Humpty Dumpty Option 2: Mono to Stereo: This option is used to merge contributing mono DNA resources across multiple child clades of the donor into a composite stereo kit. The resulting stereo output kit cannot be used to reconstruct individual ancestors of the donor, but may make a nice kit to generate matches on third party sites, as it will generally represent the most complete version of a reconstructed donor's genome that can be assembled using your available data. However, only select this option if the mono input kits were created by extracting data that spans multiple child clades with respect to the donor. For example, this is a great tool for merging data from multiple runs of the Missing Parent tool with the same available parent but multiple children. You will typically get the best results by first combining all data within clades using Option 1, and then merging the mono output kits corresponding to each clade using Option 2. | ||
*Humpty Dumpty | **Humpty Dumpty Option 3: Merge Factory Kits on Different Templates: This option is used to merge multiple factory kits pertaining to the same living donor to create a single output kit capturing data recorded at all SNPs represented in the individual input kits. For example, if you tested at both Ancestry and 23&Me, this will combine the data and create a more detailed profile of your genome that will contribute to higher resolution reconstructions of your ancestors. | ||
=== Special Phase Scripts === | === Special Phase Scripts === | ||
*Two-Parent Phase: This free tool creates high resolution phased output kits when DNA of both parents of a child donor is available. | '''*Two-Parent Phase:''' This free tool creates high resolution phased output kits when DNA of both parents of a child donor is available. | ||
*Missing Parent: This free tool creates a partial reconstruction of an unavailable parent when the DNA of the opposite parent of the child donor is available. Typically this creates a 50% reconstruction, but creates a 47% reconstruction if the child is a male and the missing parent is also a male because men do not inherit an X chromosome from their father. | |||
'''*Missing Parent:''' This free tool creates a partial reconstruction of an unavailable parent when the DNA of the opposite parent of the child donor is available. Typically this creates a 50% reconstruction, but creates a 47% reconstruction if the child is a male and the missing parent is also a male because men do not inherit an X chromosome from their father. | |||
*Reverse Phase: This tool allows users to phase their DNA using the DNA of a child rather than a parent. In the free version of the tool, users are instructed to follow a multi-step workflow including phasing and chromosome mapping. There is also an automated subscription version of the workflow which can be initiated by creating a smart project. | '''*Reverse Phase:''' This tool allows users to phase their DNA using the DNA of a child rather than a parent. In the free version of the tool, users are instructed to follow a multi-step workflow including phasing and chromosome mapping. There is also an automated subscription version of the workflow which can be initiated by creating a smart project. | ||
*Phoenix: This free tool partially reconstructs a parent of a selected child donor by extracting shared DNA from family members on the same side of the family as the target parent. This is the tool works the same as the Lazarus tool on GedMatch | '''*Phoenix:''' This free tool partially reconstructs a parent of a selected child donor by extracting shared DNA from family members on the same side of the family as the target parent. This is the tool works the same as the Lazarus tool on GedMatch. | ||
*Darkside: | '''*Darkside:''' This free tool partially reconstructs a parent of a selected child donor by isolating DNA from the opposite copy of the child's chromosomes across regions where the child shares DNA segments with family members on the opposite side of the family as the target parent. | ||
*Phase Map Locker: This subscription tool allows users to store chromosome maps in the Borland Genetics database where they can be integrated into a variety of tools and workflows. | '''*Phase Map Locker:''' This subscription tool allows users to store chromosome maps in the Borland Genetics database where they can be integrated into a variety of tools and workflows. | ||
*Create a Private Project: This subscription tool allows users to organize their DNA kits into projects. Users can also invite other users who have matching kits to submit them to their projects and collaborate. There are also three types of special Smart Projects (Reverse Phase, Visual Phasing and Creeper), in which the Creeper (the site's automated assistant) guides users through complex reconstruction workflows. Visual phasing and generic Creeper Smart Projects are currently under construction, but the unfinished versions are already available to subscribers for beta testing. The Creeper-assisted Reverse Phase Smart Project workflow is already completed. | '''*Create a Private Project:''' This subscription tool allows users to organize their DNA kits into projects. Users can also invite other users who have matching kits to submit them to their projects and collaborate. There are also three types of special Smart Projects (Reverse Phase, Visual Phasing and Creeper), in which the Creeper (the site's automated assistant) guides users through complex reconstruction workflows. Visual phasing and generic Creeper Smart Projects are currently under construction, but the unfinished versions are already available to subscribers for beta testing. The Creeper-assisted Reverse Phase Smart Project workflow is already completed. | ||
*Build 36 to Build 37 Conversion Tool: This free tool allows users to paste a list of Build 36 segments from Excel and have them converted to Build 37 coordinates. This tool used to be more important when FamilyTreeDNA was using build 36 and all the other companies were using build 37. However, all the companies are now on build 37. | '''*Build 36 to Build 37 Conversion Tool:''' This free tool allows users to paste a list of Build 36 segments from Excel and have them converted to Build 37 coordinates. This tool used to be more important when FamilyTreeDNA was using build 36 and all the other companies were using build 37. However, all the companies are now on build 37. | ||
*Global Surname Search (Beta): This free tool allows users to search the database for profiles with a given surname. | '''*Global Surname Search (Beta):''' This free tool allows users to search the database for profiles with a given surname. | ||
=== Version 2 Tools === | === Version 2 Tools === | ||
*Visualize and Export Reconstructed Segment Data (Deprecated: Replaced by Ultimate Chromosome Browser and Kit Attributes screens. Ultimate Chromosome Browser can be accessed by clicking the "Chromosome Browser" button on any of the kits in a DNA Resource's match list. Kit Attributes can be accessed by clicking the "Explore in Kit Laboratory" button on any of the kits in your DNA Inventory.) | '''*Visualize and Export Reconstructed Segment Data:''' (Deprecated: Replaced by Ultimate Chromosome Browser and Kit Attributes screens. Ultimate Chromosome Browser can be accessed by clicking the "Chromosome Browser" button on any of the kits in a DNA Resource's match list. Kit Attributes can be accessed by clicking the "Explore in Kit Laboratory" button on any of the kits in your DNA Inventory.) | ||
*Script Manager (Deprecated: To be replaced by a combination of premium web tools.) | '''*Script Manager:''' (Deprecated: To be replaced by a combination of premium web tools.) | ||
*Imputer (Coming soon!) | '''*Imputer:''' (Coming soon!) | ||
=== Version 3 Tools === | === Version 3 Tools === | ||
*HIR Mapper V1.0 (Deprecated: Replaced by HIR Mapper V2.0 Premium Web tool, accessible on kit profile screens for eligible kits.) | '''*HIR Mapper V1.0:''' (Deprecated: Replaced by HIR Mapper V2.0 Premium Web tool, accessible on kit profile screens for eligible kits.) | ||
*Creeper (Original stand-alone version deprecated. Now integrated into Premium smart projects) | '''*Creeper:''' (Original stand-alone version deprecated. Now integrated into Premium smart projects) | ||
=== New Free Web Tools === | === New Free Web Tools === | ||
*Chromosome Browser (Can be accessed by clicking the "Chromosome Browser" button on any of the matches to any of the kits in your DNA Inventory.) | '''*Chromosome Browser:''' (Can be accessed by clicking the "Chromosome Browser" button on any of the matches to any of the kits in your DNA Inventory.) | ||
*Regional Project Pilot Program Membership (Qualifying kits can be submitted from the Kit Attributes screen) | '''*Regional Project Pilot Program Membership:''' (Qualifying kits can be submitted from the Kit Attributes screen) | ||
*Family Project Pilot Program Membership (Qualifying kits can be submitted from the Kit Attributes screen) | '''*Family Project Pilot Program Membership:''' (Qualifying kits can be submitted from the Kit Attributes screen) | ||
*Build 36 to Build 37 Conversion Tool (Beta) | *Build 36 to Build 37 Conversion Tool (Beta) | ||